Best Supplements for Peripheral Neuropathy

Are you looking for the best supplements for peripheral neuropathy? You have come to the right place! A significant number of pharmaceutical pills and tablets have been invented for the sole purpose of treating peripheral neuropathy. 

However, the reality is that most of the pharmaceutical medicines only hide the indications of neuropathy rather than providing a long-term cure for them. This is one of the most important reasons why this illness is getting advanced day by day and resulting in the formation of more significant and new disorders, making it difficult to find adequate healing treatment for them. 

Neuro diseases have become one of the biggest concerns in medical science nowadays because of the human brain's fragile nature, making it difficult to operate and find a cure.

However, with the help of the best supplements for peripheral neuropathy, you will be able to find a way to become healthy and whole once again.

Let’s take a look!

Our Overall #1 Rated Pick

Neuropathy Pain Relief Supplement Peripheral
  • Natural ingredients
  • Boosts your immune system
  • Backed by GMP and FDA, U.S health boards.
  • Helps with neuropathy

Developed in the U.S, this supplement is one of the best remedies for Neuro pain out there. It is recommended by highly recognized doctors, pharmacists, and nutritionists. It includes only natural ingredients and has 600mg of lipoic acid in it. It has a nutritional provision for neuropathy and is backed with ten essential vitamins. 

Developed in 2009, it has been approved by the U.S medical associations, namely GMP and FDA. This medicine backs a fit immune system to protect you from various diseases and viruses in the future.

The 10 Best Supplements for Peripheral Neuropathy Comparison Chart

The 10 Best Supplements for Peripheral Neuropathy

In this section, we review the Top 10 Supplements for Peripheral Neuropathy available for amateurs and professions.

Neuropathy Pain Relief Supplement Peripheral

Developed in the U.S, this supplement is one of the best remedies for Neuro pain out there. It is recommended by highly recognized doctors, pharmacists, and nutritionists. It includes only natural ingredients and has 600mg of lipoic acid in it. It has a nutritional provision for neuropathy and is backed with ten essential vitamins. 

Developed in 2009, it has been approved by the U.S medical associations, namely GMP and FDA. This medicine backs a fit immune system to protect you from various diseases and viruses in the future.

It is readily available to cater to your body's requirements, no matter how weak your immune system would be. Easy to swallow and digest, it is recommended for all age groups and people suffering through all types of nervous illnesses and disorders. 

It is made up by mixing 18 beneficial supplements to make it an adequate medicine for all neurological needs. There are 120 capsules in each pack and a 30-day supply. It is definitely the best organic choice for a healthy lifestyle.


  • Natural ingredients
  • Boosts your immune system
  • Backed by GMP and FDA, U.S health boards.
  • Helps with neuropathy


  • Expensive medicinal supplement
EXIR® Galatea Nerve Revitalizing Supplement

Consisting of 120 tablets in a single packing, this U.S developed medicine is one of the most beneficial in terms of nervous pains and neurological illnesses. It consists of a lot of minerals and vitamins, namely Vitamin B6, B12, A, C, E, D acid, Calcium, Phosphorus, Iodine, Magnesium, Zinc, and a lot more. 

All these minerals and vitamins support a healthy immune system and deal with neurological deficiencies found within the brain. It consists of trace elements and amino acids that are highly helpful for the nervous system of the human body. 

Also, it helps with tissue repair and heals any injury in the brain of a person, which further fastens the revival of a healthy nervous system and brain. This supplement increases blood flow, reduces unwanted feelings such as tingling, burning, and emotionlessness.


  • Contains many vitamins and minerals
  • Improves immune system
  • Worth the money
  • Helps your brain function better


  • Doesn't ship internationally
Doctor's Best Alpha-Lipoid Acid

The doctor's best sugar-free supplement is a type of medicine that aids in providing a fit metabolism and keeps the body blood sugar levels in a safe zone. Being a neurological supplement, it also provides the body with the energy it requires. 

It also supports the body's healthy defensive system by making it stronger against diseases, viruses, and various illnesses. Moreover, its assistance in the production of antioxidant nutrients such as that of vitamin C and E is somewhat to be considered as a healthy contribution.

Non-GMO, the supplementary nutrient, is soy-free as well as sugar-free. The medicine is made up by combining various nutrients and healthy non-meat, vegan supplements to make it suitable for all kinds of people.


  • Supports a full healthy immune system as well as neurological function
  • Is available in different packaging of 180 and 360 count depending on the price range
  • Mixed with various nutrients to re-enforce the human body


  • Expensive
VasoCorp Neurop Pain Relief

This supplement helps in quick pain relief for feet because it is enforced with neurop in it. Apart from the feet, it can also provide the same calmness if applied to the legs or at the head for nerve pain relief, as its main job is to provide respite from nerve discomfort. 

It helps the body by reducing numbness, burning sensations, and tingling significantly. It is easy to use and is recommended and approved by doctors and physicists. This gel is enlaced with an award-wining formulation that provides relief hastily from distress and makes you feel relaxed.

 Apart from this, its money-back guarantee is what makes it so unique and trustworthy among individuals and keeps the producers motivated by high consumer ratings.


  • Quick pain respite
  • Good for pain relief due to peripheral neuropathy
  • Available in two different sizes of 2.5 and 6 ounces
  • Payback guarantee


  • Item does not ship internationally.
Neuro Protect 100% Pure Polyenyl

This Neuro protect comes with 2.7 g of pure polyenylphosphatidylcholine (PPC) per portion. It is different from all other Neuro products readily available in the market as it consists of no other phospholipids other than PPC and DLPC that may help with better absorption.

Research has proved that PPC ingestion increases choline flow in the blood and allows the brain to relax. A daily dose of PPC helps the liver and brain to work properly. It keeps the cholesterol levels normal and protect against intestinal problems. The medication's purpose is not to treat or cure any disease rather than just to give temporary relaxation and reduction in the illness.


  • Healthy
  • Helps organs in functioning better
  • Relaxes the body
  • Increases choline flow


  • Not widely available due to low stock.
NuSci Pure ALA RS

This powder contains pure RS-alpha Lipoic Acid ALA Powder. The powder doesn’t have any preservatives or non-organic items and chemicals to enhance its taste or effect. 

Another characteristic is that it is easily soluble in water; this solvent doesn't take much time to mix itself with water. Talking about its expiration, the product can stay fresh for almost 1.5-2.5 years. 

It should be stored in a dark and cool place, away from sunlight and heat to keep it preserved for a long time. However, the consumer should be above the legal age to consume this product and do not use it without a doctor's prescription.


  • Natural Ingredients
  • Available in different sized bottles
  • Highly nutritious
  • Easily soluble


  • It is relatively expensive than some other products
Nerve Pain Neuropathy & Diabetic Sleep Support

These pills contain ten high-quality ingredients that help people suffering from neuropathy. This nerve pain medicine was developed for the relaxation of mind and ease of body. This supplement should be added to your diet if you want to get relief from peripheral neuropathy. 

Not only would it give you a deep sleep but also increase your productivity and strength as a good rest is key to all fitness and power. It contains Lavender, Passion Flower, L-Tryptophan, Glycine, 6 mg melatonin organic valerian root, and chamomile, L-theanine, Ginkgo Leaf in it. Such a variety of minerals found in it make it one of the best nerve pain medicines present in the market. It also helps in reducing hormone imbalances.

The best thing about this product is that the company provides a 30 days money-back guarantee if you are not satisfied with the pills.


  • Full payback guarantee under the period of a month if unsatisfied
  • Helps with nerve pain
  • Helps with insomnia
  • Affordable
  • Natural Ingredients


  • The item does not ship internationally.
Alpha-Lipoic Acid CR

This product helps with hormone imbalances that result due to peripheral neuropathy. It is made in certified labs (cGMP0) so that you get safe, clean, and standardized supplements. The labs pass the yearly FDA and NSF review process, so you can rest assured about its quality.

The supplement is manufactured on a limited scale and is only provided through trademark healthcare doctors and physicians.


  • Highly reputable brand
  • These pills contain all the adequate nutrients required for the healthy working of a body
  • Help keep the fat and sugar levels at a low
  • Tested and approved by various health labs


  • Low in stock due to high demand so therefore, first come first serve rule.
Liposomal Magnesium & L-arginine cream

This cream is made for the relaxation of the body, to soothe the joints and give you solace. The lotion contains magnesium. It increases the flow of blood in the body because of the magnesium and L-Arginine present in it. It also increases circulation in hands and feet and eradicates all bruises and blood marks quickly under the body. 

High skin diffusion and amalgamation increase its capacity to heal muscle spasms and aches in various parts of the body. Composed of organic aloe, coconut oil, and other essential oils, it penetrates fast into the human body. 

The cream is odor-free and does not consist of any artificial ingredients.


  • Consists of healthy oils
  • The cream has no smell
  • Free of all preservatives
  • Takes away all types of nerve pains


  • Because of high demand not readily available and therefore stock is decreased.
Now Supplements Alpha Lipoic Acid

The pack of these medicinal pills comes with 120 tablets and is free of all preservatives. It does not contain any fake color, false flavor, milk, and corn or milk by-products. It is manufactured in the U.S. It is kosher and dairy free. No nuts are present, neither is soy or gluten. It is one of the best quality products found out in the health market. 

This natural supplement increases the efficient working of the body; therefore, they help you in feeling relaxed at night, energetic in the daytime, and free of all restlessness. It has a high consumer rating and favorable buyer reviews because of its greater quality and effects it has on the body. The product comes with GMP assurance. It recycles Vitamins E and C, and also increases the production of glutathione.


  • Contains natural and pure ingredients
  • It has 120 capsules in one packing
  • High customer reviews
  • Works great for people suffering from peripheral neuropathy


  • Due to increased demand, the stocks are low and, therefore, difficult to buy in bulk.

Buying Guide

Peripheral Neuropathy

Peripheral Neuropathy refers to the sickness of the nervous system and the nerves which carry instructions from the human brain to the rest of the body and from the body to the brain. Such an illness results in improper functioning not only of the brain but also of the human anatomy.

The peripheral nerves make a unique system in the body. They provide a connection between the brain, spinal cord, and the rest of the body, including muscles, skin, and inner organs. Often, damage to a single nerve would result in an effect on the dermatomes, which can be linked back to specific parts of the body. Injuries to these nerves impair the signal being transferred from the brain to other specific parts of the body. This, in return, could also have long term impacts not only on the nervous system but can also cause temporary paralysis, weak eye-sight, the faintness of muscles, and memory loss.

Our peripheral nervous system controls the functions of autonomous, sensory, and motor nerves. If these nerves are damaged, it can cause you to lose sensation in your hands and feet. In severe conditions, you feel pain as well. 

Benefits of Peripheral Neuropathy supplements

Neuropathy supplements have both nerve-related, and non-nerve related advantages on a large scale. However, in some cases, their advantages go past that of prescribed medicines by practitioners. A few of their benefits are as follows.

  1. Nerve Repair

These supplements are helpful in nerve repair. They help the brain with the healing of the injured nerve cells. The supplements also help in the development and basic functioning of the already existing cells by improving their health. 

They also support the process of various nerve functions and enhance the myelination of nerve tissues for better protection. Moreover, other than nerve repair, neuropathy supplements also provide a high level of assistance in controlling the symptoms of neuropathy such as numbness, sensitivities, tingling, and various pain sensations.

  1. Removal of Toxins

Due to nerve injury, several neurotoxins are created in the body. Toxins are also produced as the result of cellular metabolism. Peripheral Neuropathy supplements have strong antioxidants that restrict the production and after-effects of neurotoxins and all supplementary free-flowing radicals in the nerve cells of a person's body.

  1. General Body Nutrition

Peripheral Neuropathy supplement consists of various ingredients such as vitamins and minerals that give the body the necessary nutrients it needs for healthy working. For instance, vitamin B12 is accountable for the creation of red blood cells that transfer oxygen in the body for better cellular metabolism.

Moreover, the two nutrients, alpha-Lipoic acid, and L-Carnitine are effective antioxidants that significantly decrease the dangers and adversity of oxidative pressure. Apart from this, many other ingredients that provide the necessary diet for the body while topical additives also contribute to greatly increasing the strength of the body. 

There are few things that you need to look at when it comes to peripheral neuropathy supplements.

Let’s take a brief look at them.


For the regeneration of nerves and relief from pain, there are certain herbs and vitamins which are necessary. Always look for good quality ingredients since a few supplements may have harmful ingredients in them as well.

The main ingredients of the peripheral neuropathy supplements are briefly discussed below.

The means of working for all neuropathy-based medications rely on the ingredients that are used to create them. Active components are those components that directly treat neuropathy and symptoms of the disease. Let’s take a look at the best ingredients in a supplement for neuropathy.

  1. Alpha Lipoic Acid

Alpha lipoic Acid is an antioxidant that removes the effects of oxidative stress present in nerve cells. In high glucose environments, ALA helps in reducing the amount of lipid peroxide.

Moreover, many studies show that ALA helps in decreasing the protein glycosylation of the human body. Moreover, it increases the activity of ATPase in the neurons. This helps with proper functioning of the nerves.

  1. Vitamin B

When it comes to homeostasis, Vitamin B plays an important role. Moreover, these Vitamins play their part in nerve repair, neuroprotection, neurogenesis, etc. According to various studies, Vitamin B acts as anti-inflammatory in case of peripheral neuropathy.

Peripheral neuropathy is also sometimes referred to as vitamin B deficiency. This vitamin is highly essential for a healthy nervous system. Dosage should include vitamins B-1, B6, and B12. Vitamin B-1 is said to reduce body pains. B12, on the other hand, is so essential that deficiency of such a vitamin can result in permanent brain damage.

  1. Acetyl-L-Carnitine

Another active ingredient found in various peripheral neuropathy supplements is Acetyl-L-Carnitine. You trace the mechanism of action of this ingredient easily. Peripheral neuropathy is induced due to various reasons, such as HIV, diabetes, chemotherapy, etc. This ingredient is used to treat all of these kinds of neuropathy.

Cancer medication causes mitochondrial damage inside the human body. Acetyl-L-Carnitine helps in reversing that damage. It also helps in movement of fatty acids across cell membranes to help with production of energy.

It also reduces the production of neurotoxins by decreasing the number of lipid peroxides, and other free radicals present in the nerves. It increases the energy levels, forms healthy nerve cells, and decreases Neuro pain in people who are suffering from neuropathy.

  1. Capsaicin

Capsaicin is mostly present in topical peripheral neuropathy supplements. There are C-fibers present in nerves which release a neuropeptide, Substance P, which helps in relieving pain.

All of the ingredients that we have discussed briefly above are the active ingredients in most of the neuropathy supplements. There are various other herbs and supplements as well that are beneficial when it comes to treating peripheral neuropathy.


Bioavailability tells the amount of drug that gets absorbed by the human body. The level of supplement present in the urine tells the bioavailability of the ingredient. A supplement that is effective has a high bioavailability of 90% or more. The bioavailability of the drugs is affected by various factors as well.

Supplements that have natural ingredients are easily absorbed in the human body.


When it comes to supplements, the major issue is finding the correct dosage. You can’t take more than the recommended dosage as it will have harmful effects. When herbs are used in supplements, it becomes even more difficult to determine the correct dosage. However, look for correct dosage on the medicine label or call the manufacturer to get the details.


What is neuropathy?

Neuropathy in easy terms means the damage that has been caused to our nerves. The word peripheral neuropathy means neural illnesses inside the brain. Peripheral neuropathy usually occurs as a result of diabetes mellitus. However, neuropathy is also seen in patients suffering from HIV, after the process of chemotherapy and people who have lower back nerve injuries. Symptoms that commonly occur in case of peripheral neuropathy are tingling, numbness, pain, etc.

For how long should Vitamin B be taken?

When talking about the consumption of these supplements, we'll have to take into account two main things: Quantity and dosages per day. 

In case of Vitamin B, we should always remember that consumption of more than 200 mg of B6 per day can be harmful. Foods that are rich in this vitamin are eggs, fish, cereals, vegetables, meat, and all other types of seafood, etc. 

In the case of people who have been diagnosed with type 1 diabetes should remember that 300mg of Vitamin B6 has any significant effect. On the other hand, vitamin B can also have certain side effects if taken with other medications. So don't take it without a prescription. It should be taken for 2 years on average basis.

For how long should Alpha Lipoic Acid and amino acids be taken?

Moving onto Alpha-Lipoic, a person can take up capsules of 600-1200 mg each day. Foods that are rich in Alpha-Lipoic Acid are spinach, broccoli, brewer's yeast, liver, etc. Amino acids such as acetyl-L-Carnitine that boost the immune system of the body should be taken at an average of 500 mg per day. Dietary sources for amino acids include fish, dairy products, meat, and poultry, etc.

How to use capsaicin cream for peripheral neuropathy?

For a capsaicin cream mostly, you don't need a prescription by some practitioner. Just dab a little on the skin and rub it slowly. It is often used up for three months.

Is there a way to treat Peripheral Neuropathy?

Whenever there comes a debate regarding the cure of a particular illness, the first thing that comes to mind is diagnosis. However, when searching for the diagnosis of peripheral neuropathy, a physical exam and full medical history, including any neurological disorders in the past, are to be taken into account. Moving on to the cure of peripheral neuropathy, several things should be listed as beneficial. Firstly, pain relievers such as (Conzip, Ultram) containing high concentrations of opioids and tramadol are recommended. Anti-seizure medications such as gabapentin (Gralise, Neurontin, Horizant) and pregabalin (Lyrica) are specially developed to treat diseases such as epilepsy and nerve pains.

Final Words

There is a possibility that nerve pain and nerve injury could completely change your life. The source from which the pain originates doesn't matter, what matters is the drastic effects it can have on a human's life. Diabetes, fibromyalgia, chemotherapy, or god forbid an unprecedented accident are responsible for peripheral neuropathy. 

The best a person can do here is to find the cure to this disease as soon as he or she can. The quicker you can diagnose your symptoms, the faster you'll be able to get the necessary treatment to make yourself fit again. 

Most of the doctors provide high dosage painkillers to tackle the disease. There are many side effects of medicines, especially painkillers. We have put together this review article to help you find the top 10 best supplements for peripheral neuropathy naturally.

Here’s to a happier, healthier you!