Best Supplements For Neuropathy

The symptoms of neuropathy are debilitating and affect life output and productivity. However, these symptoms, as well as their underlying etiology, can be treated by using many synthetic and natural neuropathy supplements. 

The most common cause of neuropathy is type II Diabetes Mellitus. Diabetic neuropathy is often called diabetic peripheral neuropathy because it is found mainly in the upper and lower extremities of the body, precisely in the limbs. It is the leading cause of the non-traumatic amputation of the affected area of the body, mostly legs, and arms.

A lot of pharmaceutical medications have been designed to treat neuropathy, while some are undergoing clinical trials. However, most of these medications only mask the symptoms of neuropathy without improving the underlying nerve damage.

Neuropathy support supplement is designed to augment the effects of prescription drugs and improve the overall health of body nerves. Most of them improve neuropathy by providing nutrients and improving blood supply to nerve cells. Some are pills, while others are creams or oils for topical application. However, they are all useful in relieving the symptoms of neuropathy and healing nerve damage.

There are many neuropathy support supplement in the market. However, this article will show you the best 10 supplements based on popular reviews.

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The 10 Best Neuropathy Supplements Comparison Chart

The 10 Best Neuropathy Support Supplement

In this section, we review the Top 10 Neuropathy Support Supplement

Neuropathy Pain Relief Supplement Peripheral

Nuturna Neuropathy Support Supplement comes first on our list for many fantastic reasons. This supplement contains 600mg of Alpha Lipoic Acid (ALA), which is the most potent neuropathy relief ingredient in most prescription drugs. Besides, it contains over 15 organic ingredients; including 10 Doctor recommended dietary parts. Examples are thiamine, Vitamin B12, Vitamin C, benfotiamine, and Carnitine.

This supplement improves nerve nutrition by increasing the flow of blood to the nerves and supplying essential nutrients and energy to nerve cells. It further provides numerous essential vitamins to neural cells to activate complex biochemical processes for neural regeneration and growth.

Essential vitamins like thiamine and benfotiamine that are found in this supplement are potent therapeutic agents for relieving symptoms of diabetic neuropathy such as pain, numbness, tingling, shooting, and burning in the lower extremities of the body, precisely the feet, and toes. Also, Acetyl-L-Carnitine improves the sensitivity of vibration in the limbs, while Nuturna B vitamins relieve symptoms of associated vitamin deficiency.

Nuturna Neuropathy Support Supplement also supports the immune system. The pills are easy to swallow and have no offensive flavors. This supplement has worked for many persons, especially patients whose neuropathy is associated with type 2 diabetes mellitus. 


  • It has no after taste
  • It is easy to swallow
  • Does not cause indigestion
  • Long-term solution


  • Expensive
  • Can cause hives
  • Awful asparagus smell
Frankincense Neuropathy Rubbing Essential Relief

Frankincense and Myrrh Neuropathy Rubbing Oil is another incredible product for relieving neuropathic symptoms. It is formulated with essential oils and designed to provide topical relief for all known symptoms of diabetic peripheral neuropathy, shingles, and fibromyalgia.

This rubbing oil contains many other essential oils, plant extracts, herbal green woods, and plant spices that make it a perfect medicinal blend for relieving a wide range of neuropathy related symptoms. It also has an active analgesic property that mimics the conventional non-steroidal anti-inflammatory drugs (NSAIDs) and alleviates both acute and chronic inflammatory problems. 

It is super easy to use. With a simple topical application and gentle massage, the bioavailability and effectiveness of this rubbing oil are incredible. This rapid and efficient bioavailability makes it a perfect target medication that should be applied at the exact location of the symptoms you intend to relieve.

Frankincense and Myrrh Neuropathy Rubbing Oil isn’t a permanent solution to neuropathy. It is a temporary relief agent for burning pains, dull aches, shooting pains, cold and heat sensitivities, numbness, tingling, muscle weakness, inflammatory reactions, twitching, and stabbing sensations. It will definitely help any user move easier, sleep better, and live happier. 


  • Fast-acting
  • Rapid bioavailability
  • Target topical application
  • Easy to use


  • Not a permanent solution
  • The strong smell that could be offensive and allergic
Nerve Renew All Natural Neuropathy Alternative

Nerve Renew Natural Neuropathy Supplement is a popular supplement amongst diabetic clinicians and patients. However, it is a broad spectrum neuropathy support supplement that is also used to provide fast relief for both acute and chronic inflammatory problems, Lyme disease, vitamin deficiency, and other nerve damage complications.

It contains potent neuropathy relief ingredients. Alpha Lipoic Acid that improves the nerve blood supply and nutrient-rich B vitamins and vitamin D. It also provides many powerful antioxidants that neutralize the effects of neurotoxins that cause tingling and numbness in the extremities of the body.

One striking feature of Nerve Renew is its bioavailability and effectiveness when compared to other neuropathy support pills. Clinical trials and research have shown that Nerve Renew is three-times more bioavailable, effective, and faster than other supplements. It contains a high dose of a Vitamin B1 (thiamine) alternative called benfotiamine. Benfotiamine is absorbed three-times faster than thiamine.

Nerve Renew is also indicated for protein synthesis, nerve regeneration, nerve protection, and nerve growth. It reduces pain, tingling, and numbness, and provide short term energy boost for better movements, and sleep.


  • Easy and fast absorption
  • Contain antioxidants
  • Decrease nerve pain
  • Direct-acting


  • Expensive
  • Short term effects
Neuropathy Shingles Fibromyalgia Restoring Soothing

Relievz Neuropathy Soothing Lotion is another topical relief for neuropathy symptoms. However, it is patented, Doctor recommended, and really useful. It could be best described as a lotion from Mother Nature because of its natural ingredients. It contains Olive oil, which is natural oil. It also contains lecithin, a natural emulsifier, and a natural sugar extract like honey. Besides, it contains starch-modified Aloe Vera, which is a natural plant extract. It also contains sodium chloride, which are the naturally occurring table salts.

In addition to these, Relievz Neuropathy Soothing Lotion contains Alpha Lipoic Acid, a potent antioxidant that removes free radicals from nerve cells, improves neuronal blood supply, and nerve regeneration. Also, it contains methylcobalamin, which is a better variant of Vitamin B12, benfotiamine, and other natural flavors. It contains no chemicals or pills smell and shows no debilitating side effects that are often associated with chemical pills or creams.

It is used for relieving the symptoms of diabetic peripheral neuropathy, shingles, fibromyalgia, and Chemotherapy-induced nerve damage, which include pains, tingling, numbness, twitching, and pin and needle sensation. 

It is also fast-acting, and its effects are noticeable from the third day of application. However, this depends on the extent of the nerve damage. Nonetheless, significant results are observed in three weeks of religious use (2-3 times per day). 


  • No chemical content
  • Easy to apply
  • Patented
  • Fast-acting
  • Restore nerve function


  • Temporal relief
  • Terrible smell
  • Effects depend on the extent of nerve damage
  • List Element
  • List Element
NerveReverse Neuropathy Support Formula Supply

Here comes number five! Nerve Reverse Neuropathy Support Formula! This product could be summarized in two words: it works! This product is designed to treat your neuropathy and not just mask the symptoms. It is formulated with the right ingredients in the right quantity for nerve nutrition, repair, regeneration, and growth. 

Nerve Reverse contains Alpha Lipoic Acid (ALA), a powerful antioxidant that removes free radicals in nerve cells that result from cellular metabolism. ALA also facilitates the supply of nutrients and oxygen to nerve cells for growth and energy production. In addition to ALA, benfotiamine, a variant of thiamine (Vitamin B1) that is less water-soluble, three-times more bioavailable, and effective in Neuroprotection, and nerve nutrition are present. It also contains methylcobalamin that improves the overall health of the nerves.

Many clinicians recommend precisely for diabetics peripheral neuropathy, and it progressively relieves pains, tingling, numbness, and sensitivities that come with nerve damage. It is sold with a fantastic guarantee and refund policy offer if it doesn’t work after 90 days.


  • Easy to swallow
  • Treats the underlying cause of neuropathy
  • Doctor recommended
  • Amazing guarantee, and refund policy


  • Causes drowsiness
Advanced Neuropathy Formula Ubiquinol Vegetarian

NerveQQ Ultra Advanced Neuropathy Nerve Support Formula is an incredible supplement for nerve damage repair, and healing. It contains two active ingredients: NaturalPQQ and Ubiquinol. These two ingredients combine by fermentation to produce NerveQQ. In addition to these two active ingredients, NerveQQ contains other natural ingredients like purified water, soy, lecithin, sunflower seeds, and modified starch that makes it safe to use. It has no synthetic chemicals, sugar, and artificial flavors, and it has little or no side effects when compared to synthetic products.

Ubiquinol in NerveQQ triggers the production of Nerve Growth Factor (NGF), which improves nerve conduction velocity, myelin sheath insulation, and strength of nerve impulse. Nerve Growth Factor (NGF) also triggers the growth and branching of nerve cells, and repair cellular and cognitive damage in the brain. It improves nerve function, neurogenesis, Neuroprotection, and repair age-related nerve damage. 

The effects of NerveQQ are seen after some time with religious use (1-2 times daily). Also, there are no restrictions on food or beverage intake when using NerveQQ soft gels. The only underside of this neuropathy support supplement is that it contains carrageenan, which is a well-known carcinogen.


  • Improves nerve, brain, muscle cell function
  • No restrictions on food or beverage
  • No significant side effects
  • Non-synthetic supplement


  • · Contain carcinogen
PEAORA POLY 500TM Palmitoylethanolamide Trans Resveratrol

PEAORA POLY 500 is a broad spectrum neuropathy support supplement that is used for treating many other pain-related conditions like acute inflammation, interstitial cystitis, bladder pain, and neuropathy pain. It is formulated with two significant ingredients: palmitoylethanolamide (PEA), and polytrol (POLY).

Palmitoylethanolamide is fatty amide that has an active anti-inflammatory property. It blocks the necrosis factor (NF), which is the central stimulant of both acute and chronic inflammation. Polytrol is a trans-resveratrol variant that has a potent antimicrobial, and anti-nociceptive (pain relief) property.

It also has many vitamins and mineral complexes like Vitamin D3, magnesium, and calcium that make it a whole body improving supplement. It is also indicated for improving body immunity and the healing process of bladder injuries. 

PEAORA POLY 500 also has an excellent antioxidant property, and it removes neurotoxins and free radicals of nerve cell metabolism. It also improves Neuroprotection and nerve cell damage. Also, this supplement inhibits convulsions. However, it can cause allergic reactions in sensitive persons and should be used upon prescription or recommendation from a health professional.


  • Provide whole-body nutrition
  • Anti-inflammatory, anti-nociceptive, antimicrobial, and antioxidant property
  • Easy to use
  • Improves Neuroprotection
  • Treats many disease conditions


  • Expensive
  • Allergic to a sensitive person
Clinical Strength Neuropathy Relief Advanced

Nuturna Neuropathy Nerve Pain Relief Cream is another excellent product from Nuturna that brings about rapid nerve pain relief, and nerve cell damage. This excellent topical cream is formulated from pure therapeutic ingredients like menthol, Tea Tree Leaf Oil, Vitamin B6, Vitamin E, and Aloe Vera. It has a uniquely soft texture and a sweet, creamy scent. It is easy to use, and it does not stain clothes or leave a greasy feeling on the skin.

It is a versatile neuropathy support cream that penetrates the skin and activates the specialized sensory pathways underneath the skin surface to restore normal sensations in the area where it is applied. It also penetrates the skin, acts on the exact source of pain, and reduces other inflammatory reactions like swelling and redness. It also increases blood circulation to damaged nerve cells to provide adequate nutrition for neurogenesis and healing. It promotes Neuroprotection and sustains the normal functioning of healthy nerve cells. 

Nuturna Neuropathy Support cream is fast-acting. It provides an intense cooling and soothing relief for numbness, tingling, twitching, and shooting pains within minutes. It also moisturizes and improves the overall health of the skin.


  • Fast-acting
  • Attack pain at the source
  • Versatile
  • Rapid skin penetration


  • Strong menthol scent
  • Expensive
NeuropAWAY Nerve Support Formula Neuropathy

VasoCorp NeuropAway Pain Relief is a phenomenal neuropathy support supplement relieving the symptoms of various types of neuropathy. It is perfect for reducing numbness, burning, tingling, swelling, and neuropathic pains. Generally, it improves blood supply to nerve cells, maintains uniform conduction velocity, improves healthy nerve function, and relieves symptoms of neuropathy within a short period. 

NeuropAway contains powerful natural ingredients such as Taurine, Citrulline, Carnitine, Alpha Lipoic Acid, and B vitamins. 

Taurine supports neurological development and reverses the painful symptoms of diabetic peripheral neuropathy. 

Carnitine helps nerve fiber regeneration, and increase vibration perception of nerve cells. Citrulline improves the nerve blood supply and protects nerve cells from ischemia. Alpha Lipoic Acid improves nerve conduction velocity and removes neurotoxins that cause an excitotoxic sensation in peripheral neuropathy. B vitamins, especially thiamine (Vitamin B1), and Methylcobalamin (Vitamin B12) also increases blood circulation, and provide nutrition for nerve repair, and growth. 

NeuropAway also has an ingredient that is not found in other supplements: alanine. Alanine binds to and increases peripheral nerve excitability and sensitivity. It is fast-acting, and begins to show marked effects 3-5 days after commencement of treatment. The manufacturer also has a fantastic guarantee offer and refund policy.


  • Fast-acting
  • Contain new alanine
  • Mask symptoms, and support recovery
  • Have a long term healing effect


  • Causes loose stool
  • Contains melatonin
Neuropathy Capsaicin Regenerate Tingling Numbness

Vita Sciences Neuropathy Nerve Pain Relief Cream comes last on our list. This topical neuropathy support supplement is an everyday pain relief lotion that is infused with many topical vitamins and minerals. Such as Vitamin B12 (Methylcobalamin), Vitamin B1, Vitamin B5, Vitamin B6, Vitamin E, Arnica, and Capsaicin (a natural pepper extract for neuropathy pain relief) inaccurate, measured doses. 

It is easy to use, highly absorbent and deep penetrating. Nervex induces nerve repair, and provide relief for common symptoms of diabetic peripheral neuropathy like numbness, tingling, burning, shooting, and stabbing pain after a protracted period of use. It also relieves the symptoms of fibromyalgia and others in non-diabetic neuropathy.

It is odorless, non-irritating, hypoallergenic, and safe for those who have sensitive skin, or type 1 hypersensitivity like asthma. It contains high-grade moisturizers like coconut oil that aid rapid penetration into deep nerves to attack the pain at its source. It also contains powerful antioxidants that remove free radicals in nerve cells and support the functioning of healthy nerve cells.

Vita Sciences Neuropathy Nerve Pain Relief Cream is has a convenient, easy to use, and calibrated pump that delivers the right amount of lotion. It doesn’t leave a greasy feel, and it has a gentle feel on the skin. It is important to note that it could cause burning when applied to open wounds and highly sensitive skin. However, you can use gloves to apply it if your hands are highly sensitive.


  • Odorless
  • Hypoallergenic
  • Contain essential vitamins and minerals
  • Highly absorbent, and deeply penetrating
  • Gentle and non-greasy


  • Could cause burning on sensitive skin
  • Takes some time to show effects

How Does Neuropathy Supplements Work?

The mechanism of action for all neuropathy support supplements depends on the individual active ingredients that are used to formulate them. Active ingredients are those ingredients that directly treat neuropathy and their associated symptoms. Other components only have mechanical effects like aiding penetration, good texture, better scent, etc.

There are many active ingredients in most neuropathy support supplements. This section will outline the most common active ingredients and how they work to bring about the desired results. 

Alpha Lipoic Acid

Alpha Lipoic Acid is a potent antioxidant that helps reverse the onset and impact of oxidative stress in nerve cells. The mechanism of action behind this antioxidant function is decreased lipid peroxidation. ALA reduces the amount of lipid peroxide in a high glucose environment. 

Further studies also show that ALA reduces protein glycosylation and increases ATPase activity in nerve cells, which improves the normal functioning of nerves. Another critical action of ALA has increased microcirculation in nerve tissues for adequate nutrition and support. 

B Vitamins

B Vitamins play essential roles in the maintenance of general body homeostasis. However, they also have specific roles in neurogenesis, nerve repair, recovery of nerve function, and Neuroprotection. Evidence also shows that B Vitamins have anti-nociceptive and anti-inflammatory properties for neuropathy associated pain relief. 

Although their mechanism of action isn’t too precise, animal studies and clinical trials suggest that B Vitamins work by blocking metabolic damage pathways. Modulating neural excitability, activating protein synthesis, inhibiting oxidative stress and sensory nerve pathways, and preventing some nociceptive synaptic transmissions. 


Acetyl-L-Carnitine is another active ingredient that is found in most neuropathy support supplements. It has a more traceable mechanism of action, and it is used to treat both diabetic peripheral neuropathy, HIV induced neuropathy, and chemotherapy-induced neuropathy. 

It counteracts the mitochondrial damage of cancer drugs, and promotes the trans-membrane movement of fatty acids for cellular energy production. It also potentiates the nerve cell receptors to nerve growth factor (NGF), and inhibits neurotoxicity by reducing lipid peroxides, and other free radicals in neural circulation.


Capsaicin is mostly found in topical neuropathy support supplement, and it has a precise mechanism of action. It stimulates afferent C-fibers, which stimulates the release of Substance P, a neuropeptide that is involved in pain relief. 

These are the principal active ingredients in most neuropathy support supplements, and their suggested mechanisms of action. Other herbs and components are also undergoing research, even when they show marked effects when used for treatment.

Benefits Of Neuropathy Support Supplements

Neuropathy support supplement has many nerve-related and non-nerve related interests. In some cases, their benefits supersede that of prescription drugs. This section will highlight some of these benefits:

Nerve Repair

The active ingredients of these supplements are designed to trigger the repair of damaged nerve cells, and the growth and normal functioning of healthy ones. They also support nerve function like conduction velocity and improve the myelination of nerve tissues for protection. In addition to nerve repair, neuropathy support supplements also provide significant relief for neuropathy related symptoms like numbness, tingling, burning, sensitivities, and various pain sensation.

Removal of Toxins

Neurotoxins and other free radicals are both indicators and stimulants of nerve damage. They’re often the product of cellular metabolism. Neuropathy support supplements have potent antioxidants that inhibit the production, and impact of neurotoxins, and other free radicals in nerve cells. 

General Body Nutrition

Neuropathy support supplement contains many ingredients like vitamins and minerals that provide general nutrition for the body. For example, Vitamin B12 is involved in the production of blood-red cells which transport oxygen for cellular metabolism. 

Furthermore, Alpha Lipoic Acid and L-Carnitine are potent antioxidants that reduce the risk and health hazards of oxidative stress. There are other herbs like Aloe Vera that provide nutrition for the body, while topical supplements also improve the overall health of the skin.


What is neuropathy?

Neuropathy simply means nerve damage. The term “peripheral neuropathy” is used to describe nerve damage at the extremities of the body. This is often due to diabetes mellitus. However, neuropathy is also seen in HIV infection, after chemotherapy treatments, and lower back nerve damage. Common symptoms include numbness, tingling, abnormal sensitivities, and pain. 

Can neuropathy be cured?

Presently, there is no permanent cure for neuropathy. All medications are aimed at preventing further nerve damage and manage their discomforting symptoms. 

Can Neuropathy Support Supplements be taken with other medicines?

Yes! However, this depends on the ingredients of the supplement. As a general rule, always see your Doctor with your neuropathy support supplement before you start taking it.

Are there other benefits of Neuropathy Support Supplements?

Yes! Kindly scroll up and read on the benefits of neuropathy support supplements.

Are Neuropathy Support Supplements Safe?

Most neuropathy support supplements have no significant side effects. They are often made with few synthetic ingredients, and they work like dietary supplements. 

Are there side effects?

Every neuropathy support supplement has both pros and cons. However, these are not adverse drug reactions. They’re mostly allergies that depend on the user sensitivity. However, some contain carcinogenic ingredients. Always research the parts of a neuropathy support supplement before you buy it.

Can I use Neuropathy Support Supplements when I have no symptoms?

Yes, but it is better to get a general dietary supplement instead. Neuropathy support supplements are somewhat specific for neuropathy.

Can I use Neuropathy Support Supplements when I have no symptoms?

Yes, but it is better to get a general dietary supplement instead. Neuropathy support supplements are somewhat specific for neuropathy.

Where can I buy Neuropathy Support Supplements?

You can get them in local drug patent stores, community pharmacies, and online stores like Amazon and Walmart. 

What Should I look out for before I choose?

Generally, check the constituent ingredients, the bioavailability, and drug indications. 

How much does it cost?

The price of neuropathy support supplements varies from product to product and from store to store.

Final Words

Neuropathy has become the most significant challenge facing diabetics all over the world. It is the most common cause of non-traumatic amputation, and there’s no permanent cure for it until now. However, numerous clinical studies and trials are ongoing to find a permanent solution to neuropathy and especially diabetic peripheral neuropathy. 

This has resulted in some prescription drugs and supplements that have provided much relief for many neuropathic patients. Recent results have shown that neuropathy support supplements do better than prescription drugs in the management of diabetic peripheral neuropathy. However, the market is already saturated with many products. 

However, this article will guide you in choosing the best neuropathy support supplement for your nerve symptoms. Kindly scroll up and reread it.