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Parkinson's disease is a chronic and progressive
degenerative disorder of the central nervous system that impairs motor skills,
speech and other functions. It is usually characterized by muscle rigidity,
tremor, postural instability, and a slowing or loss of physical movement.
Ageing is an important risk factor, and the incidence of
Parkinson's increases with age, although about 4% are diagnosed before the age
of 50. An estimated 7-10 million people worldwide (roughly 1 in 1,000 of the
total population) are thought to be living with Parkinson's.
A high proportion of sufferers also experience mild cognitive impairment as the disease advances, including executive dysfunction (impaired problem solving, fluctuations in attention, etc), slowed cognitive speed and memory problems, particularly with working memory, episodic memory and with recalling learned information. In many cases (about 25-30% of cases), this eventually develops into full-blown dementia, although memory problems in Parkinson's are typically milder than in Alzheimer's disease. Non-motor symptoms such as memory loss remain the most under-addressed area for research into Parkinson's disease.
Parkinson's disease is the result of decreased stimulation
of the motor cortex by the basal ganglia, usually due to the insufficient
formation and action of the neurotransmitter dopamine in the neurons in an area
of the brain called the substantia nigra. When cells that normally produce
dopamine die off, the symptoms of Parkinson’s often appear. Its main cause is
thought to be genetic, although the exact mechanism is still unclear.
There is no cure for Parkinson's, but some limited effect in
counteracting the effects can be provided by treatment involving drugs which
help boost the brain’s production of dopamine such as levodopa, or dopamine
agonists that mimic the action of dopamine, as well as some other more
experimental and controversial treatments. However, most of the drugs have some
unpleasant side-effects, and some non-motor symptoms may actually be aggravated
by the treatments used for the motor symptoms.